Database of dynamic renal scintigraphy
Database of dynamic renal scintigraphy 2014
(5 data sets - adults, children, and 3 sets of simulated data)
Dynamic renal study database extension and update in April-May 2014
In April-May 2014, the database www.dynamicrenalstudy.org has been extended by 4 additional data sets. As the result, it contains the following 5 groups of dynamic renal studies:
1) drsprg
| number of studies: | 107 raw scintigraphic studies in adults (inadequate studies no. 3, 30, 33, 36, 43, 51, 103, 109 excluded) |
| number of image files: | 587 image files in DICOM and Interfile format |
| patients: | 45 men and 62 women, age 15 - 86 (53.1 ± 18.4) years, with measured weight and height 45 - 143 (80.0 ± 19.0) kg and 145 - 192 (168.4 ± 9.7) cm |
| image data: | 99mTc-MAG3 studies in posterior and anterior projections recorded in a single acquisition group - 180 images, 128 x 128 pixels, 10 sec frames (30 min acquisition) in 106 patients completed by post-voiding images (posterior and anterior projection) in 76 patients completed by 2 transmission scans for accurate attenuation correction, in 27 patients completed by furosemide injection in 13 - 22 min (during the study) |
| clinical data: | diagnosis of renal disease, blood pressure before and after the study, estimated GFR > 89 ml/min 28 patients, 60 - 89 ml/min 19 patients, 30 - 59 ml/min 29 patients, 15 - 29 ml/min 19 patients, < 15 ml/min 12 patients, relative function of the left kidney 0 - 91 % (arithmetic mean 49 ± standard deviation 20 %) |
| laboratory data: | serum creatinine (n = 60) 0.54 - 11.74 (2.44 ± 2.02) mg/100 ml, or 48 - 1038 (216 ± 179) μmol/l serum urea (n =60) 16 - 286 (88 ± 58) mg/100 ml, or 2.7 - 47.1 (14.5 ± 9.5) mmol/l creatinine clearance (n = 56) 3 - 177 (48.1 ± 41.2) ml/min, or 0.05 - 2.95 (0.80 ± 0.69) ml/s |
In all patients, one blood sample was taken at 36 - 68 (48 ± 5) min for in vitro 99mTc-MAG3 activity measurement and calculation of 99mTc-MAG3 plasma clearance. The database contains individual sampling times and measured counts after corrections for background and decay.
In 54 patients, 51Cr-EDTA was applied simultaneously with 99mTc-MAG3 and 2 blood samples taken at 97 - 169 (135 ± 10) min and at 221 - 249 (239 ± 5) min to calculate GFR. The database contains individual sampling times and measured counts after corrections for background and decay.
specific application options: this data set offers a wide spectrum of measured data rather than calculated results - therefore it can be used to develop and test the new and existing methods of measurement of total renal function in scintigraphic data and to compare their results with 99mTc-MAG3 plasma clearance (that can be also calculated using various methods preferred by a user), to develop and test the new and existing methods for attenuation correction and to compare their results with accurate attenuation correction obtained by transmission measurement, to experiment with geometric mean of the two conjugate views, etc; the data can be also used for clinical audits, inter-laboratory comparisons, for development and testing of analytic methods and clinical software, and for teaching and training purposes
contact: Martin Šámal, Charles University Prague, Czech Republic, [email protected]
references:
Samal M, Valousek J. Clinically documented data set of dynamic renal scintigraphy for clinical audits and quality assurance of nuclear medicine software. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39(Suppl. 2):S170-171 (abstract OP087)
2) drsbru
| number of studies: | 100 raw scintigraphic studies in children | |||||||||||||||||||||||||||
| number of image files: | 185 image files in DICOM and Interfile format | |||||||||||||||||||||||||||
| patients: | 65 boys and 35 girls, age 0 - 17 (4.5 ± 4.6) years | |||||||||||||||||||||||||||
| image data: | 99mTc-MAG3 studies in posterior projection recorded in a single acquisition group - 120 images, 128 x 128 pixels, 10 sec frames (20 min acquisition) in 85 patients completed by post-voiding images in posterior projection in all patients, relative renal function of the left kidney measured by 2 different methods (integral method and Patlak-Rutland plot) and 2 outflow parameters (normalised residual activity NORA and output efficiency OE in the end of the 20 minute study and in post-micturition PM images) are calculated and presented in the supporting tables | |||||||||||||||||||||||||||
| clinical data: | diagnosis of renal disease LK relative function (integral method) 0 - 100 % (48 ± 19 %) LK relative function (Patlak-Rutland plot) 0 - 100 % (48 ± 19 %)
|
|||||||||||||||||||||||||||
| laboratory data: | GFR 22 - 133 ml/min (arithmetic mean 78 ± standard deviation 21 ml/min) | |||||||||||||||||||||||||||
specific application options: this data set offers a collection of dynamic renal studies in children of all age groups with a wide range of renal pathology and renal function [Tondeur et al 2013] including measured GFR (plasma clearance of 51Cr-EDTA) and reference data of relative function and outflow indices measured by experienced nuclear medicine expert - therefore the data can be used for teaching and training as well as for development, testing and validation of clinical and experimental software, for clinical audits and for inter-laboratory comparisons
contact: Amy Piepsz, Department of Nuclear Medicine, CHU Saint-Pierre, Brussels, Belgium, [email protected]
references:
Tondeur M, Nogarede C, Donoso G, Piepsz A. Inter- and intra-observer reproducibility of quantitative renographic parameters of differential function and renal drainage in children. Scandinavian Journal of Clinical and Laboratory Investigation 2013; 73(5):414-421, doi 10.3109/00365513.2013.797597
3) drshyb
| number of studies: | 19 simulated studies with 19 levels of relative renal function |
| number of image files: | 38 image files in DICOM and Interfile format (2x 19 with 2 different levels of kidney-to-bacgkround ratio, low and high) |
| image data: | 99mTc-MAG3 studies in posterior projection recorded in a single acquisition group - 120 images, originally 64 x 64 pixles interpolated into 128 x 128 pixels, 10 sec frames (20 min acquisition) |
| image data: | 99mTc-MAG3 studies in posterior projection recorded in a single acquisition group - 120 images, originally 64 x 64 pixles interpolated into 128 x 128 pixels, 10 sec frames (20 min acquisition) |
data description: Data set drshyb_001-019 includes 19 dynamic renal studies in posterior projection simulated as 'hybrid phantoms', i.e. the real patient data modified in a known way [Samal and Bergmann 1997, 1998]. Selected patient study was decomposed to individual dynamic structures (renal parenchyma, pelvis, vascular and tissue background) using factor analysis of dynamic image sequences [Samal et al 1998, Bergmann et al 1999] and then recomposed again with known simulated tracer dynamics within each structure.
Image data represent simulated raw dynamic renal studies in posterior projections with stepwise (5%) increment of left-kidney relative function from 5 to 95 %. Each study with specific relative function is presented with 2 levels of kidney-to-background ratio (low and high). The data sets illustrate relative easiness of accurate measurement of relative renal function of 40-60 % and growing difficulty and uncertainty of measurement with unilaterally decreasing kidney function. The data can be used to validate clinical software for the measurement of relative renal function.
contact: Martin Šámal, Charles University Prague, Czech Republic, [email protected]
references:
Samal M, Bergmann H. Hybrid phantoms for quality assurance of the software for dynamic radionuclide studies. Eur J Nucl Med 1994; 21(8):805 (abstract 321)
Samal M, Bergmann H. The second generation of hybrid phantoms. Eur J Nucl Med 1995; 22(8):757 (abstract A 126)
Samal M, Bergmann H. Hybrid renal phantoms. pp 63-68 in Cosgriff PS (editor). Quality assurance of nuclear medicine software. COST B2 final report. EUR 17916 EN. European Communities, Directorate-General Science, Research and Development, Luxembourg, 1997 (ISBN 92-828-1501-3)
Samal M, Bergmann H. Hybrid phantoms for testing the measurement of regional dynamics in dynamic renal scintigraphy. Nucl Med Commun 1998;19:161-171.
Samal M, Nimmon CC, Britton KE, Bergmann H. Relative renal uptake and transit time measurements using functional factor images and fuzzy regions of interest. Eur J Nucl Med 1998; 25(1):48-54.
Bergmann H, Dworak E, König B, Mostbeck A, Samal M. Automatic separation of renal parenchyma and pelvis using fuzzy regions of interest. Eur J Nucl Med 1999; 26(8):837-843
4) drslund
| number of studies: | 6 simulated studies varying in injected activity, total and split renal function |
| number of image files: | 30 image files in DICOM and Interfile format (each study presents a specific combination of total and split renal function with 2 different levels of injected activity and one reference study) |
| image data: | 99mTc-MAG3 studies in posterior and anterior projections recorded in a single acquisition group - 120 images, 128 x 128 pixels, 10 sec frames (20 min acquisition) |
data description: Data set drslund_001-006 includes 6 dynamic renal studies simulated with the help of 99mTc-MAG3 pharmacokinetic multi-comparment model, 3D digital phantom of human torso (XCAT), and Monte Carlo simulation of scintigraphic study (SIMIND), as it is described in detail by the authors [Brolin et al, 2013].
Image data represent simulated raw dynamic renal studies in posterior and anterior projections in a female patient of the weight 69 kg and height 163 cm. Simulated absolute and relative renal function as well as injected activity and the volume of renal and other body structures are given in the supplement (tables). A unique feature of this data is that each study is completed by "golden standard" reference study, as if the kidneys and the heart were observed in the air without tissue background and attenuation.
The data are very realistic and can be used to validate and test clinical software with respect to known simulated values of total and relative renal function as well as for estimation of kidney volumes. If the corrections (background subtraction, attenuation correction) applied to the study by a user are correct, diagnostic indices extracted from the data simulated in the human body should be identical with those simulated in the air. The data can be also used with the benefit of known truth for many other purposes.
contact: Gustav Brolin, Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden, [email protected]
references:
Brolin G, Sjögren Gleisner K, Ljungberg M. Dynamic 99mTc-MAG3 renography: images for quality control obtained by combining pharmacokinetic modelling, an anthropomorphic computer phantom and Monte Carlo simulated scintillation camera imaging. Physics in Medicine and Biology 2013, 58:3145-3161, doi:10.1088/0031-9155/58/10/3145.
Brolin G, Granerus G, Olsson A, Edenbrandt L, Ljungberg M. A new method for Monte Carlo simulations of dynamic scintillation camera imaging: 99mTc-MAG3 renography studies. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39(Suppl. 2):S170 (abstract OP086)
5) drsmich
| number of studies: | 3 simulated studies of a physical phantom recorded by gamma camera |
| number of image files: | 3 image files in DICOM and Interfile format |
| image data: | 99mTc-MAG3 studies in posterior and anterior projections recorded in the two acquisition groups - 60 images 128 x 128 pixels, 1 sec frames and 144 images 128 x 128 pixels, 10 sec frames (total 25 min acquisition) |
data description: Data set drsmich_001-003 includes 3 dynamic renal studies 99mTc-MAG3 obtained by scintigrpahic examination of a physical phantom developed by dr Jari O. Heikkinen [Heikkinen 2004]. Recently, physical phantom studies were used for inter-laboratory comparison studies in Finland and UK. Reports on the comparisons have been published in Nuclear Medicine Communications 2014 [Nykänen et al 2014, Nijran et al 2014].
Study drsmich_001 represents normal kidney function. Study drsmich_002 simulates obstruction in the left kidney. Study drsmich_003 simulates dilated pelvis in the left kidney. Details on simulated functions, relative renal function, attenuation, etc, can be found in the supplement (tables) and in the reports by Nykänen and Nijran. Principal purpose of using physical phantoms is to test accuracy of physical measurement by gamma camera. The studies included in the database illustrate high quality of resulting data from the physical phantom. The data can be also used to reproduce simulated parameters in a similar way as with the mathematical phantoms.
contact: Jari O. Heikkinen, Department of Medical Physics, Etelä-Savo Hospital District, Mikkeli Central Hospital, Mikkeli, Finland, [email protected]
references:
Heikkinen JO. A dynamic phantom for radionuclide renography. Physics in Medicine and Biology 1999; 44:N39-N53
Heikkinen JO, Kuikka JT, Ahonen AKA, Rautio PJ. Quality of dynamic radionuclide renal imaging: multicentre evaluation using a functional renal phantom. Nuclear Medicine Communications 2001; 22:987-995
Heikkinen JO, New automated physical phantom for renography. Journal of Nuclear Medicine 2004; 45:495-499
Heikkinen J, Nykänen A, Aarnio J, Rautio P. Multicentre evaluation of renography with a new automated physical phantom: a follow up after 1997. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39(Suppl. 2):S171 (abstract OP088)
Hakala M, Sutinen K, Gröhn H, Lyyra-Laitinen T, Heikkinen J. The evaluation of inter-individual variation in dynamic renal imaging. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39(Suppl. 2):S633 (abstract TP092)
Nykänen AO, Rautio PJ, Aarnio JV, Heikkinen JO. Multicenter evaluation of renography with an automated physical phantom. Accepted for publication in Nuclear Medicine Communications 2014
Nijran KS, Houston AS, Fleming JS, Jarritt PH, Heikkinen JO. UK audit of analysis of quantitative parameters from renography data generated using a physical phantom. Accepted for publication in Nuclear Medicine Communications 2014
